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Updated: Jun 19, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
Dismissing links between HPV and aggressive tongue cancer in young patients
1Department of Surgery, Al-Bayader Hospital, 8th Circle, Amman 11814, Jordan. alwikah@hotmail.com
Background:
The objective of this study is to disprove and dismiss etiological links between human papillomavirus (HPV) and aggressive tongue cancer in young patients.
Methods:
Review of available literature with focus on presenting the epidemiological, histological and immunohistochemical arguments against an association between HPV and aggressive glossal neoplasm in younger populations.
Conclusion:
HPV is not associated with the recent surge in the incidence of biologically aggressive oral cavity cancer in young populations.
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