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Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased by a...
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Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...
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Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
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Related Experiment Video

Updated: Jun 19, 2026

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
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A case of duplicitous diplococci.

M Raychaudhuri1, A Peall, C Page

  • 1Department of Genitiourinary Medicine, Cardiff Royal Infirmary, Cardiff CF24 0SZ, UK. rcmalini@yahoo.co.uk

Sexually Transmitted Infections
|October 15, 2009
PubMed
Summary

Disseminated gonococcal infection (DGI) is rare but more common in women. This case highlights how a lupus flare can mask DGI symptoms, emphasizing the need for careful diagnosis in patients with systemic lupus erythematosus.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Rheumatology

Background:

  • Disseminated gonococcal infection (DGI) is a rare complication of Neisseria gonorrhoeae infection.
  • DGI occurs more frequently in women and can be associated with complement deficiencies.
  • Systemic lupus erythematosus (SLE) can predispose individuals to infections, including gonococcal bacteremia.

Observation:

  • A case of DGI is presented in a patient with a history of SLE.
  • The initial presentation of DGI was obscured by an active lupus flare.
  • This diagnostic challenge highlights the complexity of co-existing conditions.

Findings:

  • The patient presented with symptoms that mimicked a lupus flare but was ultimately diagnosed with DGI.
  • Complement deficiencies, either inherited or episodic, are key risk factors for DGI, especially in the context of autoimmune diseases like SLE.

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  • Prompt recognition and treatment of DGI are crucial to prevent severe complications.
  • Implications:

    • This case underscores the importance of considering DGI in patients with SLE experiencing flares, even when symptoms overlap.
    • Clinicians should maintain a high index of suspicion for DGI in SLE patients presenting with suggestive symptoms.
    • Understanding the interplay between autoimmune conditions and infectious diseases is vital for effective patient management.