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Updated: Jun 19, 2026

Use of Synaptic Zinc Histochemistry to Reveal Different Regions and Laminae in the Developing and Adult Brain
Published on: October 29, 2017
Zinc in the physiology and pathology of the CNS
Stefano L Sensi1, Pierre Paoletti, Ashley I Bush
1Department of Basic and Applied Medical Science, Molecular Neurology Unit, CeSI-Center for Excellence on Aging, University G. dAnnunzio, Chieti, 66013, Italy. ssensi@uci.edu
Abstract:
The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology. The recent development of powerful tools, including zinc-sensitive fluorescent probes, selective chelators and genetically modified animal models, has brought a deeper understanding of the roles of this cation as a crucial intra- and intercellular signalling ion of the CNS, and hence of the neurophysiological importance of zinc-dependent pathways and the injurious effects of zinc dyshomeostasis. The development of some innovative therapeutic strategies is aimed at controlling and preventing the damaging effects of this cation in neurological conditions such as stroke and Alzheimer's disease.
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