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Updated: Jun 19, 2026

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A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening
Published on: October 16, 2015
A general electrochemical method for label-free screening of protein-small molecule interactions
Kevin J Cash1, Francesco Ricci, Kevin W Plaxco
1Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Abstract:
Here we report a versatile method by which the interaction between a protein and a small molecule, and the disruption of that interaction by competition with other small molecules, can be monitored electrochemically directly in complex sample matrices.
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