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[Plasma lipids and interleukins in geriatric patients with ischemic heart disease]
Insights
Elderly patients with ischemic heart disease show altered cytokine profiles, indicating inflammation and autoimmune responses, even with normal lipid levels. Specific correlations between apolipoproteins and cytokines were identified.
Area of Science:
- Cardiology
- Immunology
- Biochemistry
Context:
- Ischemic heart disease (IHD) affects elderly individuals, often presenting with complex metabolic and inflammatory changes.
- Assessing the relationship between lipid profiles, apolipoproteins, and cytokine levels is crucial for understanding IHD pathophysiology in aging populations.
Purpose:
- To investigate the cytokine spectrum in elderly patients with IHD and its correlation with lipid and apolipoprotein levels.
- To determine if inflammatory and autoimmune markers are altered in aging IHD patients despite adequate lipid profiles.
Summary:
- This study examined 184 patients (60-95 years) with IHD, measuring serum lipids, apolipoproteins, and cytokines.
- Pronounced changes in cytokine levels, including increased interleukin-1 beta and -6, and tumor necrosis factor-alpha, were observed.
- Significant correlations were found between specific apolipoproteins (Apo-B1, LP alpha, ApoB1/Apo-A1) and IL-6, with inverse correlations noted for Apo-B1 and IL-6, and apolipoprotein A1 with various cytokines.
Impact:
- Findings suggest that inflammatory and autoimmune processes play a significant role in IHD in the elderly, independent of traditional lipid markers.
- Identifies specific cytokine-apolipoprotein correlations that may serve as predictive markers for IHD in older adults.
- Highlights the need for further research into targeted immunomodulatory therapies for IHD in aging populations.
Abstract:
One hundred and eighty-four patients aged 60-95 years who had ischemic heart disease (IHD) were examined. The serum levels of total cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins, apoA- and apoB-lipoproteins, calcium, phosphorus, alkaline phosphatase, etc. were measured on a Vitalab Flexor E. biochemical analyzer. The content of cytokines was determined by solid-phase immunoassay using the Protein contour test systems (State Research Institute of Particularly Pure Biologicals, Saint-Petersburg) on a Stat Fax photometer. There were pronounced changes in the cytokine spectrum in elderly and senile persons despite the fact that they had an adequate lipid spectrum. The increased levels of interleukin (IL)-1 beta and IL-6 suggest that there is an inflammatory reaction whereas those of tumor necrosis factor-alpha may be indicative of the body's autoimmune readiness. There was a high direct correlation of the content of apolipoproteins Apo-B1 and IL-6, as well as LP alpha and IL-6; ApoB1/Apo-A1 and IL-6. A high inverse correlation was found in the content of Apo-B1 and IL-6, which is a poor predictor in old age group patients. There was a mean correlation in the levels of apolipoproteins (B1 and B alpha) and the cytokines IL-1 beta, IL-4, IFN-gamma, TNF-alpha, and IFN-alpha; and there was a mean inverse correlation between the concentrations of apolipoproteins A1 and these cytokines.
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