Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Left ventricular deformation in chronic schizophrenia-a detailed analysis from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study.

Quantitative imaging in medicine and surgery·2026

Same author

The Variant T Allele of <i>SLC2A1</i> rs841847 Confers Moderate Protection Against Late-Onset Alzheimer's Disease.

Biomolecules·2026

Same author

Volumetric and Functional Features of Left Atrium in Chronic Schizophrenia-Detailed Analysis from Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study.

Biomedicines·2026

Same author

Temporal Parameters of Spontaneous Speech as Early Indicators of Alcohol-Related Cognitive Impairment.

Journal of clinical medicine·2026

Same author

Identifying genetic differences between bipolar disorder and major depression through multiple genome-wide association analyses.

The British journal of psychiatry : the journal of mental science·2025

Same author

Premenstrual dysphoric disorder-an undervalued diagnosis? A cross-sectional study in Hungarian women.

Comprehensive psychoneuroendocrinology·2024

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

[Depression as chronobiological illness].

Janos Kálmán¹, Sára Kálmán

¹SZTE Pszichiátriai Klinika. kalmanj@nepsy.szote.u-szeged.hu

Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet Lapja = Official Journal of the Hungarian Association of Psychopharmacology

|October 16, 2009

Summary

This summary is machine-generated.

Chronobiological problems significantly impact psychiatric disorders, particularly mood and sleep disturbances. Advances in chronobiology offer new therapeutic strategies, including pharmacotherapy and non-pharmacological interventions for depression.

More Related Videos

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Animal Models of Depression - Chronic Despair Model (CDM)

Animal Models of Depression - Chronic Despair Model (CDM)

Published on: September 23, 2021

Related Experiment Videos

Last Updated: Jun 19, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Animal Models of Depression - Chronic Despair Model (CDM)

Animal Models of Depression - Chronic Despair Model (CDM)

Published on: September 23, 2021

Area of Science:

Psychiatry
Chronobiology
Neuroscience

Background:

Chronobiological disruptions are implicated in the etiology and progression of psychiatric disorders.
Mood and sleep disorders are significantly influenced by circadian, ultradian, and seasonal rhythms.

Purpose of the Study:

To review recent advances in chronobiology research relevant to clinical practice.
To emphasize the psychobiology and pharmacotherapy of depression from a chronobiological perspective.

Main Methods:

Review of current literature on chronobiology, psychobiology, and pharmacotherapy of depression.
Analysis of the role of internal clock systems, including molecular and neuro-humoral regulation.
Examination of chronobiological interventions and their clinical applications.

Main Results:

Internal biological clocks, regulated by clock genes and melatonin, govern human behavior.
Social interactions also modulate biological clock systems.
Agomelatine, a selective melatonin receptor agonist, demonstrates antidepressant effects by targeting circadian rhythm desynchronization.

Conclusions:

Chronobiological desynchronization is a key factor in affective disorders, manifesting as sleep disturbances and other physiological abnormalities.
Melatonin profiles can serve as biomarkers for age, gender, and neuropsychiatric conditions.
Chronobiotics and non-pharmacological interventions like light therapy and sleep deprivation offer viable treatment options.