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Updated: Jun 19, 2026

Ex Vivo Expansion and Genetic Manipulation of Mouse Hematopoietic Stem Cells in Polyvinyl Alcohol-Based Cultures
07:55

Ex Vivo Expansion and Genetic Manipulation of Mouse Hematopoietic Stem Cells in Polyvinyl Alcohol-Based Cultures

Published on: February 10, 2023

[Trends in stem cell manipulation ex vivo]

Drago Batinić1

  • 1Referentni centar za klinico-laboratorijsku imunodijagnostiku hematoloskih i imunoloskih bolesti, Zavod za imunologiju, Klinicki zavod za laboratorijsku dijagnostiku Medicinskog fakulteta Sveucilista u Zagrebu, Klinicki bolnicki centar Zagreb, Zagreb, Hrvatska. drago.batinic@zg.t-com.hr

Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti
|October 16, 2009
PubMed

Hematopoietic stem cell transplantation (HSCT) is nowadays a standard procedure for the treatment of malignant and non-malignant diseases of bone marrow and immune system as well as of malignant solid tumors. However, HSCT is often complicated by serious and often fatal conditions, which initiated development of a number of techniques of cell manipulation ex vivo in the last two decades, with the aim of improving the graft quality and thus the outcome of transplantation. The subject of this brief review is graft manipulation in autologous and allogeneic HSCT, with emphasis on the future directions in cell therapy and regenerative medicine.

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