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[Cardiac rhythm variability in chronic bronchial asthma]
Klinicheskaia Meditsina
|October 16, 2009
Summary
Cardiac rhythm variability (CRV) in bronchial asthma (BA) reveals autonomous dysregulation of the sinoatrial node. High-resolution rhythmocardiography may aid pulmonologists in diagnosing BA.
Area of Science:
- Cardiology
- Pulmonology
- Medical Diagnostics
Background:
- Bronchial asthma (BA) is often associated with complex physiological changes.
- Understanding cardiac rhythm variability (CRV) offers insights into autonomic nervous system function.
Purpose of the Study:
- To investigate CRV in patients with bronchial asthma.
- To determine the diagnostic significance of CRV in BA.
- To explore the relationship between CRV and bronchial obstruction.
Main Methods:
- Studied 265 patients with BA using rhythmocardiography (KAP-RK-01 "Mikor").
- Employed statistical and spectral analysis of CRV under targeted stimulation.
- Correlated CRV parameters with spirometry and peak flowmetry, and assessed changes post-bronchodilator.
Main Results:
- BA patients exhibited autonomous dysregulation of sinoatrial node (SAN) activity, with suppressed peripheral vegetative influence and SAN functional incompetence.
- Observed unique CRV patterns in BA, including decreased variability, altered sympato-parasympathetic influence, and enhanced humoral/metabolic effects.
- Identified very low-frequency CRV waves (35.332 ± 8.773 s) associated with bronchial obstruction, confirmed by bronchodilator response and spirometry.
Conclusions:
- Bronchial asthma is linked to specific sinoatrial node dysregulation patterns.
- High-resolution rhythmocardiography can reveal CRV abnormalities in BA.
- This technique shows potential for practical use by pulmonologists in diagnosing and managing BA.
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