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[Risk of cardiovascular complications in patients with frequent hypertensive crises]

I P Kolos, I E Chazova, S N Tereshchenko

    Terapevticheskii Arkhiv
    |October 16, 2009
    PubMed

    Insights

    Frequent uncomplicated hypertensive crises (UHC) significantly increase the risk of stroke, heart failure, and left ventricular hypertrophy in hypertensive patients. However, UHC frequency does not impact myocardial infarction risk.

    Area of Science:

    • Cardiology
    • Neurology
    • Hypertension Research

    Context:

    • Hypertensive patients are at risk for cardiovascular complications.
    • Uncomplicated hypertensive crises (UHC) represent a significant clinical challenge.
    • Understanding the impact of UHC frequency on cardiovascular outcomes is crucial for patient management.

    Purpose:

    • To investigate the association between the frequency of uncomplicated hypertensive crises (UHC) and the risk of cardiovascular complications in patients with hypertension.
    • To compare the relative risk of various cardiovascular events in patients experiencing frequent UHC versus rare UHC.

    Summary:

    • A retrospective case-control study involving 863 hypertensive patients (305 with frequent UHC, 558 with rare UHC) found that frequent UHC correlated with a longer history of hypertension and poorer blood pressure control.
    • Patients with frequent UHC exhibited significantly higher risks of non-fatal stroke/transient ischemic attack (OR 1.94), chronic cardiac failure (OR 1.64), left ventricular hypertrophy (OR 2.11), and myocardial ischemia (OR 2.05).
    • The frequency of UHC did not show a significant association with the risk of non-fatal myocardial infarction (OR 1.34).

    Impact:

    • Frequent UHC are identified as a significant risk factor for cerebrovascular events, heart failure, and left ventricular hypertrophy.
    • These findings highlight the importance of managing UHC frequency to mitigate serious cardiovascular complications.
    • The study suggests that interventions targeting UHC frequency may be beneficial in improving long-term cardiovascular health in hypertensive individuals.
    Abstract

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