Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective and sensitive recognition of Zn<sup>2+</sup> by a dansyl-derived peptide sensor.

RSC advances·2026
Same author

Peptide structure and silver ion affinity: influence on the formation of α-helices upon metal binding.

Chemical communications (Cambridge, England)·2026
Same author

Schiff Base Heterometallic Complexes and Their Potential Applications.

Crystal growth & design·2026
Same author

50 Years of Giese Reaction - a Personal View.

Angewandte Chemie (International ed. in English)·2025
Same author

Coping with the Blues: Simple and Photo-Stable Dye for Long-Term Live-Cell Imaging.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025
Same author

Self-Immolative Arylcarbonates for Nucleic Acid Templated Reactions.

The Journal of organic chemistry·2025

Related Experiment Video

Updated: Jun 19, 2026

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
07:14

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers

Published on: May 12, 2023

Multitopic ligand design: a concept for single-source precursors.

Fabienne Gschwind1, Olha Sereda, Katharina M Fromm

  • 1University of Fribourg, Department of Chemistry, Chemin du Musée 9, CH-1700 Fribourg, Switzerland.

Inorganic Chemistry
|October 16, 2009
PubMed
Summary
This summary is machine-generated.

A novel multitopic ligand coordinates alkaline earth metal ions via O-donors and group 11 elements via N-donors. This enables the creation of mixed-metal compounds for advanced materials applications.

More Related Videos

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

Synthesis of a Water-soluble Metal&#8211;Organic Complex Array
06:40

Synthesis of a Water-soluble Metal–Organic Complex Array

Published on: October 8, 2016

Related Experiment Videos

Last Updated: Jun 19, 2026

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
07:14

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers

Published on: May 12, 2023

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

Synthesis of a Water-soluble Metal&#8211;Organic Complex Array
06:40

Synthesis of a Water-soluble Metal–Organic Complex Array

Published on: October 8, 2016

Area of Science:

  • Coordination Chemistry
  • Materials Science
  • Inorganic Chemistry

Background:

  • Multitopic ligands are crucial for constructing complex metal-organic frameworks.
  • Designing ligands for selective coordination of different metal ions is a key challenge.
  • O,O'-bisnicotinic acid tetraethylene glycol (L) offers distinct donor sites for versatile metal binding.

Purpose of the Study:

  • To investigate the coordination behavior of the multitopic ligand L with different metal ions.
  • To demonstrate the ligand's ability to bridge alkaline earth metals and group 11 elements.
  • To explore the potential of resulting compounds as single-source precursors for mixed-metal oxides.

Main Methods:

  • Synthesis and characterization of calcium complexes using ligand L.
  • Preparation and structural analysis of a copper(I) coordination polymer network.
  • Formation and characterization of mixed-metal compounds incorporating both Ca(2+) and Cu(+).

Main Results:

  • The O-donor atoms of ligand L selectively coordinate to alkaline earth metal ions like Ca(2+).
  • The N-donor atoms of ligand L effectively bind to group 11 elements, exemplified by Cu(+).
  • A mixed-metal compound was successfully synthesized, serving as a precursor for mixed-metal oxide materials.

Conclusions:

  • Ligand L is a versatile multitopic ligand capable of coordinating distinct metal ion types.
  • The designed ligand facilitates the formation of compounds containing both alkaline earth and group 11 metals.
  • The synthesized mixed-metal compounds show promise as single-source precursors for advanced oxide materials.