Related Experiment Video

Updated: Jun 19, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

[Relationship between plasma cortistatin and coronary heart disease]

Qing Ping Tian1, Xue Ru Feng, Yong Zheng Pang

  • 1Department of Geriatric, Peking University First Hospital, Beijing 100034, China.

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences
|October 16, 2009
PubMed

Insights

Patients with coronary heart disease (CHD) exhibit elevated plasma levels of cortistatin (CST). Factors like triglyceride and total cholesterol negatively correlate with CST, while diabetes mellitus and myocardial infarction history show positive correlations, suggesting CST

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Biochemistry

Context:

  • Coronary heart disease (CHD) is a leading cause of mortality worldwide.
  • Understanding novel biomarkers for CHD is crucial for risk stratification and management.
  • Cortistatin (CST) is a recently identified peptide with potential roles in cardiovascular physiology.

Purpose:

  • To investigate the association between plasma cortistatin (CST) levels and coronary heart disease (CHD).
  • To identify clinical factors influencing CST levels in patients with and without CHD.
  • To assess the impact of percutaneous coronary intervention (PCI) on CST levels.

Summary:

  • Plasma CST levels were significantly higher in CHD patients compared to healthy controls.
  • PCI procedure did not alter CST levels.
  • CST levels showed no correlation with fasting blood glucose, hsCRP, LVEF, or lesion severity.
  • Triglyceride and total cholesterol levels negatively correlated with CST, while a history of diabetes mellitus (DM) or myocardial infarction (MI) positively correlated with CST.

Impact:

  • Elevated CST levels in CHD patients suggest its potential involvement in CHD pathogenesis.
  • CST may serve as a novel biomarker for CHD.
  • Further research is warranted to elucidate the precise role of CST in cardiovascular disease.
  • Understanding CST's relationship with metabolic factors and prior cardiac events could inform therapeutic strategies.
Abstract

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...