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Fixed drug eruption resulting from fluconazole use: a case report
Journal of Medical Case Reports
|October 16, 2009
Summary
Fluconazole, an antifungal, may cause fixed drug eruptions, a side effect not widely recognized. This case report highlights the need to include this reaction in fluconazole
Area of Science:
- Dermatology
- Pharmacology
- Infectious Diseases
Background:
- Fluconazole is a common antifungal medication.
- Fixed drug eruption is a potential adverse drug reaction.
- This reaction is not consistently listed as a side effect of fluconazole.
Purpose of the Study:
- To report a rare case of fixed drug eruption.
- To investigate the association between fluconazole and fixed drug eruption.
- To advocate for updating the known side effect profile of fluconazole.
Main Methods:
- A case study of a 25-year-old woman treated for vaginal candidiasis with fluconazole.
- Diagnostic procedures included patch testing, oral challenge testing, and skin biopsy.
- All tests confirmed fixed drug eruption.
Main Results:
- The patient developed fixed drug eruptions after a short course of fluconazole.
- Diagnostic tests confirmed the adverse drug reaction.
- The findings support a link between fluconazole and fixed drug eruption.
Conclusions:
- Fixed drug eruption is a potential, though not widely recognized, side effect of fluconazole.
- Misdiagnosis and mistreatment can occur due to the underreporting of this side effect.
- It is recommended to add fixed drug eruption to the official list of fluconazole side effects.
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