Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbes and Methanogenesis01:26

Microbes and Methanogenesis

Methanogenesis is a critical microbial process in anaerobic ecosystems responsible for the biological production of methane, a potent greenhouse gas and valuable biofuel. This metabolic pathway is primarily facilitated by methanogenic archaea, which thrive in anoxic environments such as wetlands, sediments, and animal gastrointestinal tracts. The absence of oxygen in these habitats prevents aerobic respiration, thereby favoring alternative biochemical pathways for organic matter degradation.In...
Microbial Interactions: Mutualism01:25

Microbial Interactions: Mutualism

Mutualism is a symbiotic interaction in which all participating organisms benefit. These relationships can be obligate or facultative and are fundamental to ecosystem functions across diverse biological systems.Plant–Fungi MutualismOne well-known example is the association between plant roots and mycorrhizal fungi, such as Rhizophagus species. The fungal hyphae penetrate the root hairs and the epidermis, forming an extensive hyphal network that establishes a symbiotic association. Through this...
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptomics profiles in intestinal sulfide overproduction, small intestinal bacterial overgrowth, and intestinal methanogen overgrowth.

mSystems·2026
Same author

Candida Enteritis Diagnoses in the United States: Prevalence and Clinical Insights from a Large Commercial Insurance Database.

Digestive diseases and sciences·2026
Same author

Association of pharmacotherapy with all-cause mortality among patients with irritable bowel syndrome.

Communications medicine·2026
Same author

A Systematic Review of Efficacy in Irritable Bowel Syndrome: How the Number Needed to Treat May be a Misleading Metric.

The American journal of gastroenterology·2026
Same author

Real-world Study of Three-gas Breath Testing Nationwide and the Association With Symptoms.

Journal of clinical gastroenterology·2026
Same author

Minor Papillotomy for Treatment of Idiopathic Acute Pancreatitis With Pancreas Divisum: A Randomized Clinical Trial.

JAMA·2026

Related Experiment Video

Updated: Jun 19, 2026

Clinical Efficacy of an Innovative Multidimensional Traction Therapy in Moderate Adolescent Idiopathic Scoliosis
07:12

Clinical Efficacy of an Innovative Multidimensional Traction Therapy in Moderate Adolescent Idiopathic Scoliosis

Published on: February 10, 2026

Methane and the gastrointestinal tract.

Ara B Sahakian1, Sam-Ryong Jee, Mark Pimentel

  • 1Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Digestive Diseases and Sciences
|October 16, 2009
PubMed
Summary

Methane, a gas produced by gut bacteria, may actively influence gut function and is linked to constipation. This review explores methane

Area of Science:

  • Gastroenterology
  • Microbiology
  • Physiology

Background:

  • Enteric fermentation produces gases like methane in the intestinal tract.
  • Methane, previously considered inert, is now recognized for its potential active effects on gut function.
  • This review focuses on methane's role in gastrointestinal health and disease.

Purpose of the Study:

  • To review the biogenesis and clinical associations of methane.
  • To examine evidence for methane's active role in gastrointestinal motility.
  • To explore potential therapeutic applications related to methane production.

Main Methods:

  • Literature review of studies on gastrointestinal gases, with a focus on methane.
  • Analysis of methane production, elimination, and its association with functional gastrointestinal symptoms.

Related Experiment Videos

Last Updated: Jun 19, 2026

Clinical Efficacy of an Innovative Multidimensional Traction Therapy in Moderate Adolescent Idiopathic Scoliosis
07:12

Clinical Efficacy of an Innovative Multidimensional Traction Therapy in Moderate Adolescent Idiopathic Scoliosis

Published on: February 10, 2026

  • Examination of recent findings on the physical and biological effects of methane on gut function.
  • Main Results:

    • Methane is produced by enteric microflora through anaerobic fermentation of carbohydrates.
    • Between 30-62% of healthy individuals produce methane, which is expelled via flatus or respiration.
    • Emerging evidence links methane to functional constipation, suggesting an active role in gut motility.

    Conclusions:

    • Methane's significance extends beyond a simple byproduct of fermentation.
    • The review highlights methane's active role in gastrointestinal motility, particularly in constipation.
    • Understanding methane's biogenesis and effects may lead to novel therapeutic strategies.