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Updated: Jun 19, 2026
10:09
Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
Published on: May 11, 2015
[Insulin and type 2 diabetes mellitus]
Andrea Lanker1, Bruno Müller, Peter Diem
1Universitätspoliklinik für Endokrinologie, Diabetologie und Klinische Ernährung, Inselspital, Universität Bern. andrea.lanker@insel.ch
Therapeutische Umschau. Revue Therapeutique
|October 16, 2009
Summary
Type 2 diabetes management often requires insulin when oral medications and lifestyle changes fail to control blood glucose. Specific conditions also necessitate insulin therapy regardless of glycemic control.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Pharmacology
Context:
- Rising global prevalence of type 2 diabetes.
- Limitations of oral hypoglycemic agents for glycemic control.
- Insulin therapy as a crucial treatment escalation.
Purpose:
- To outline indications for insulin therapy in type 2 diabetes.
- To emphasize the importance of individualized insulin regimen selection.
- To provide guidance on insulin use beyond glycemic targets.
Summary:
- Insulin treatment is indicated for type 2 diabetes when HbA1c targets (<7%) are unmet despite oral agents and lifestyle modifications.
- Pregnancy, perioperative periods, critical care, glucocorticoid use, neuropathy, and oral agent contraindications are specific indications for insulin.
- Selecting the optimal insulin regimen requires consideration of daily blood glucose profiles and individual patient needs.
Impact:
- Improved glycemic control in complex type 2 diabetes cases.
- Enhanced patient outcomes through appropriate insulin initiation.
- Personalized diabetes care strategies for diverse clinical scenarios.
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