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Related Concept Videos

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Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
08:19

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Published on: January 15, 2016

Gait apraxia in multiple sclerosis.

Nuhad E Abou Zeid1, Brian G Weinshenker, B Mark Keegan

  • 1Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905,USA.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|October 17, 2009
PubMed
Summary
This summary is machine-generated.

Gait apraxia, a specific gait disorder, can significantly impair individuals with Multiple Sclerosis (MS). This condition may be underdiagnosed, impacting patient mobility and quality of life.

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Area of Science:

  • Neurology
  • Neuroscience
  • Rehabilitation Medicine

Background:

  • Gait apraxia is a distinct gait disorder not caused by motor, cerebellar, or sensory issues.
  • Gait impairment is prevalent in Multiple Sclerosis (MS), often attributed to spasticity and ataxia.
  • Current assessment scales for MS gait impairment do not specifically evaluate apraxia.

Purpose of the Study:

  • To characterize gait apraxia in 15 patients with Multiple Sclerosis (MS) where it was the primary functional impairment.
  • To highlight gait apraxia as a significant, potentially underrecognized, cause of disability in MS.

Main Methods:

  • A retrospective review of the Mayo Clinic database from 1994 to 2007 was conducted.
  • The search terms used were "Multiple Sclerosis" and "gait apraxia".
  • Inclusion criteria included definite MS and significant gait apraxia; exclusion criteria were other causes of apraxia or predominantly spastic/ataxic gait.

Main Results:

  • The study included 15 patients, with 60% being women and 80% having progressive MS.
  • Gait apraxia appeared a median of 8 years after MS onset, with a median EDSS of 6.5.
  • Associated symptoms included cognitive dysfunction (73%) and neurogenic bladder (93%); common MRI findings were periventricular lesions and cerebral atrophy.

Conclusions:

  • Gait apraxia can lead to substantial functional disability in MS patients and may be frequently overlooked.
  • The long-term progression of gait apraxia in MS is not well understood.
  • The natural history of this specific gait disorder in MS may differ from other ambulatory impairments in the disease.