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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Published on: February 6, 2021

Postcataract endophthalmitis caused by Enterococcus faecalis.

Kuan-Jen Chen1, Chi-Chun Lai, Ming-Hui Sun

  • 1Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. cgr999chiayi@yahoo.com.tw

Ocular Immunology and Inflammation
|October 17, 2009
PubMed
Summary
This summary is machine-generated.

Postcataract surgery infections caused by Enterococcus faecalis (E. faecalis) often lead to poor vision. While E. faecalis remains susceptible to vancomycin, effective management strategies are crucial for visual outcomes.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Postcataract surgery endophthalmitis is a serious complication.
  • Enterococcus faecalis is a significant pathogen in endophthalmitis.
  • Understanding its management and resistance patterns is critical.

Purpose of the Study:

  • To analyze management strategies for E. faecalis endophthalmitis.
  • To determine susceptibility patterns of E. faecalis isolates.
  • To evaluate visual outcomes following treatment.

Main Methods:

  • Retrospective chart review of 26 patients with culture-proven E. faecalis endophthalmitis.
  • Analysis of initial treatment modalities, including pars plana vitrectomy and intravitreal antibiotics.
  • Assessment of antibiotic susceptibility, focusing on vancomycin, ampicillin, teicoplanin, and gentamicin.

Main Results:

  • Pars plana vitrectomy with intravitreal antibiotics was used in 58% of initial treatments.
  • All E. faecalis isolates were susceptible to vancomycin (0% resistance).
  • High-level gentamicin resistance was observed in 67% of tested isolates.
  • A significant proportion of patients (69%) had poor final visual acuity (light perception to no light perception).

Conclusions:

  • Enterococcus faecalis endophthalmitis typically presents with a poor visual prognosis.
  • Vancomycin remains an effective antibiotic against E. faecalis in this context.
  • High-level gentamicin resistance is a notable finding, impacting treatment considerations.