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Mitogenic activity of natural and synthetic lignins against cultured splenocytes
Y Kurakata1, H Sakagami, T Oh-Hara
1First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan.
In Vivo (Athens, Greece)
|November 1, 1990
Abstract:
Various natural lignified materials and synthetic dehydrogenation polymers (the so-called synthetic lignins) prepared from several phenylpropenoids were investigated for their mitogenic activity. All of these materials time- and dose-dependently stimulated the DNA synthesis of isolated mouse splenocytes. However, their stimulating activity was significantly decreased when the splenocytes were pretreated with anti-Thy-1.2 monoclonal antibody and rabbit complement. Natural and synthetic lignins demand attention as potential immunopotentiators.