Related Experiment Video
Updated: Jun 19, 2026

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
Published on: May 17, 2024
Haplotype-based case-control study of the human AGTR1 gene and essential hypertension in Han Chinese subjects
Sheng-jie Nie1, Tang Wen-ru, Chen Bi-feng
1Human Genetics Center of Yunnan University, #2 N. Cuihu Rd. Kunming, Yunnan 650091 PR China.
Objectives:
Essential hypertension is considered to be a multifactorial trait resulting from the combined influence of environmental and genetic determinants. The aim of the study is to assess the association between the human AGTR1 gene and essential hypertension (EH) using a haplotype-based case-control study in Han Chinese subjects.
Design And Methods:
Seven tag SNPs and the A1166C polymorphism of the AGTR1 gene were genotyped in 510 hypertension subjects and 510 normotensive subjects using PCR-RFLP method.
Results:
Single SNP analyses indicated that the rs12695895 was significantly associated with hypertension, adjusted for covariates. Compared with the other haplotypes, Hap4 (AGGACTT) which carry the susceptible rs12695895 A allele was found to significantly increase the risk of EH with odds ratios equal to 1.84 (p=0.0002).
Conclusions:
The present results indicate that rs12695895 might be a genetic marker for EH and Hap4 (AGGACTT) was associated with hypertension in Han Chinese population.
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Single Nucleotide Polymorphisms-SNPs
Hypertension I: Introduction
Hypertension III: Clinical Manifestations and Diagnostic Studies
Pharmacogenomics: Identification of New Drug Targets
