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Updated: Jun 19, 2026

Real-time Live Imaging of T-cell Signaling Complex Formation
Published on: June 23, 2013
Elucidation of T cell signalling models
Nick D L Owens1, Jon Timmis, Andrew Greensted
1Department of Electronics, University of York, UK. ndlo100@ohm.york.ac.uk
Abstract:
A potential mechanism that allows T cells to reliably discriminate pMHC ligands involves an interplay between kinetic proofreading, negative feedback and a destruction of this negative feedback. We analyse a detailed model of these mechanisms which involves the TCR, SHP1 and ERK. We discover that the behaviour of pSHP1 negative feedback is of primary importance, and particularly the influence of a kinetic proofreading base negative feedback state on pSHP1 dynamics. The CD8 co-receptor is shown to benefit from a kinetic proofreading locking mechanism and is able to overcome pSHP1 negative influences to sensitise a T cell.
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