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Anemia in renal disease: diagnosis and management

Christina E Lankhorst1, Jay B Wish

  • 1Division of Nephrology, University Hospitals Case Medical Center, 11100 Euclid Ave, Cleveland, OH 44106, USA. christina.lankhorst@uhhospitals.org

Blood Reviews
|October 17, 2009
PubMed

Insights

Anemia is a common complication of chronic kidney disease (CKD). Treating iron deficiency and using erythropoiesis-stimulating agents (ESAs) judiciously can improve patient outcomes.

Area of Science:

  • Nephrology
  • Hematology

Background:

  • Anemia is a frequent complication of chronic kidney disease (CKD), increasing risks for cardiovascular disease and faster renal failure.
  • Causes of anemia in CKD patients are multifactorial, extending beyond erythropoietin deficiency, necessitating comprehensive evaluation.

Purpose of the Study:

  • To review the management of anemia in patients with chronic kidney disease.
  • To highlight the role of erythropoiesis-stimulating agents (ESAs) and iron management.

Main Methods:

  • Literature review of anemia management in CKD.
  • Analysis of treatment strategies including ESAs and iron supplementation.

Main Results:

  • Erythropoiesis-stimulating agents (ESAs) are a primary treatment for CKD-related anemia but require careful use due to associated risks.
  • Iron deficiency frequently coexists and its correction can decrease ESA needs and improve anemia.
  • Partial anemia correction, not complete, is linked to better patient outcomes.

Conclusions:

  • Effective management of CKD-related anemia involves addressing iron deficiency and judicious use of ESAs.
  • A balanced approach to anemia correction is crucial for improving cardiovascular health and quality of life in CKD patients.

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