Related Experiment Video

Updated: Jun 19, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Eosinophilia and thrombophilia in churg strauss syndrome: a clinical and pathogenetic overview

Paul R J Ames1, Maurizio Margaglione, Sara Mackie

  • 1Haematology Department, Airedale General Hospital, Steeton and Immunoclot Ltd, Leeds, United Kingdom. paxmes@aol.com

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|October 17, 2009
PubMed

Insights

Churg Strauss Syndrome (CSS) involves vascular occlusions due to eosinophils. This review details thrombosis prevalence and pathogenesis in CSS, highlighting the role of eosinophils in clot formation.

Area of Science:

  • Rheumatology
  • Hematology
  • Pathology

Background:

  • Churg Strauss Syndrome (CSS) is increasingly associated with vascular occlusions.
  • The thrombogenic potential of eosinophils in CSS is often underestimated.
  • Understanding thrombosis in CSS is crucial for patient management.

Purpose of the Study:

  • To evaluate the prevalence of thrombosis in CSS patient series.
  • To demonstrate the potential for vascular occlusion in any anatomical location within CSS.
  • To describe the underlying mechanisms of thrombosis in CSS.

Main Methods:

  • Systematic literature search of PubMed, EMBASE, and Google for CSS series (1951-present).
  • Analysis of reported prevalence rates for arterial and venous occlusions.
  • Review of pathogenetic mechanisms involving eosinophils and ANCA.

Main Results:

  • Prevalence of arterial occlusion in CSS series ranges from 3.1% to 18.7%.
  • Prevalence of venous occlusion in CSS series ranges from 5.8% to 30%.
  • Specific surveys indicate an 8.1% prevalence of venous thromboembolism in CSS.

Conclusions:

  • Eosinophils contribute to thrombosis in CSS by releasing tissue factor and cationic proteins, promoting coagulation and platelet activation.
  • Antineutrophil cytoplasmic antibodies (ANCA) may induce a prothrombotic endothelial state.
  • Further research into CSS-associated thrombosis is warranted.

More Related Videos

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...