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Related Concept Videos

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...

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Related Experiment Video

Updated: Jun 19, 2026

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
08:09

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

Annotating non-coding transcription using functional genomics strategies.

Alistair R R Forrest1, Rehab F Abdelhamid, Piero Carninci

  • 1Omics Science Center, RIKEN Yokohama Institute, Yokohama, Kanagawa 230-0045 Japan.

Briefings in Functional Genomics & Proteomics
|October 17, 2009
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) are crucial regulators of gene expression, operating through diverse mechanisms. Recent functional genomics strategies are revealing their roles in cellular processes and gene regulation.

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Related Experiment Videos

Last Updated: Jun 19, 2026

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
08:09

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

Area of Science:

  • Molecular Biology
  • Genomics
  • Epigenetics

Background:

  • Non-coding RNA (ncRNA) transcripts do not code for proteins but regulate cellular functions.
  • ncRNAs, once overlooked, are now recognized as a major component of the cellular transcriptome.
  • Their regulatory roles in gene expression, chromatin structure, and epigenetics are diverse and complex.

Purpose of the Study:

  • To highlight recent functional genomics strategies for identifying and assigning function to ncRNA transcription.
  • To underscore the importance of ncRNAs in gene regulation and cellular processes.

Main Methods:

  • Complementary DNA (cDNA) cloning
  • Tag sequencing
  • Genome tiling array studies
  • Functional genomics strategies

Main Results:

  • ncRNAs constitute a significant portion of cellular RNA species.
  • ncRNA-based regulation acts as a 'hidden layer' controlling gene expression.
  • Mechanisms include influencing chromatin structure, epigenetics, translational, and transcriptional silencing.

Conclusions:

  • ncRNAs play vital roles in cellular processes and gene expression regulation.
  • Functional genomics approaches are essential for understanding ncRNA function.
  • Further research is needed to fully elucidate the diverse mechanisms of ncRNA action.