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Related Concept Videos

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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Related Experiment Video

Updated: Jun 19, 2026

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
12:08

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies

Published on: August 20, 2021

ABySS-Explorer: visualizing genome sequence assemblies.

Cydney B Nielsen1, Shaun D Jackman, Inanç Birol

  • 1BC Cancer Agency, Genome Sciences Centre. cydneyn@bcgsc.ca

IEEE Transactions on Visualization and Computer Graphics
|October 17, 2009
PubMed
Summary
This summary is machine-generated.

This study introduces ABySS-Explorer, a novel visualization tool that aids genome assembly by displaying global sequence structure. It replaces manual analysis, improving efficiency in large-scale genome sequencing projects.

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Last Updated: Jun 19, 2026

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
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Published on: August 20, 2021

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Novel Sequence Discovery by Subtractive Genomics
09:40

Novel Sequence Discovery by Subtractive Genomics

Published on: January 25, 2019

Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Large-scale genome sequencing projects face challenges in reconstructing complete genomes from short subsequences.
  • Manual inspection of data inconsistencies is a bottleneck in the final stages of genome assembly.
  • Existing visualization tools often focus on local errors, hindering high-level assembly inspection.

Purpose of the Study:

  • To design and present a novel interactive graph display, ABySS-Explorer, for visualizing genome assembly structure.
  • To address the limitations of current tools by emphasizing global assembly structure and integrating key data features.
  • To replace manual and time-consuming analysis tasks with an efficient visual encoding.

Main Methods:

  • Translating key data features, identified through analyst discussions, into a concise visual encoding.
  • Developing an interactive graph display that highlights global assembly structure.
  • Integrating salient data features such as sequence length into the visualization.
  • Incorporating user feedback for iterative design refinements.

Main Results:

  • ABySS-Explorer provides a novel interactive graph display for genome assembly visualization.
  • The tool emphasizes global assembly structure, overcoming limitations of local error-focused tools.
  • It integrates features like sequence length, aiding high-level inspection.
  • User feedback led to iterative design improvements, enhancing usability.

Conclusions:

  • ABySS-Explorer significantly aids genome assembly by providing a global perspective and integrating key data features.
  • The tool streamlines analysis, replacing manual and pen-and-paper methods.
  • The visual encoding demonstrates generality for DNA sequence data beyond initial design considerations.