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C-reactive protein gene variant and the human left ventricular growth response to exercise: data from The LARGE Heart

Jack J Mann1, John R Payne, Tina Shah

  • 1Centre for Cardiovascular Genetics, BHF Laboratories, Royal Free and University CollegeMedical School, London, UK.

Journal of Cardiovascular Pharmacology
|October 17, 2009
PubMed

Insights

A specific gene variant in C-reactive protein (CRP) is linked to greater left ventricular (LV) growth in response to exercise. This suggests a potential causal role for CRP in LV hypertrophy development.

Area of Science:

  • Cardiovascular Genetics
  • Exercise Physiology

Background:

  • Elevated C-reactive protein (CRP) levels correlate with left ventricular (LV) hypertrophy.
  • The relationship between CRP and LV hypertrophy may be causal or confounded by vascular disease.
  • The CRP +1444C>T gene variant influences serum CRP levels.

Purpose of the Study:

  • To investigate the association between the CRP +1444C>T gene variant and exercise-induced LV hypertrophy in young, healthy males.
  • To clarify whether CRP plays a causal role in LV hypertrophy.
  • To assess the impact of CRP genotype on LV mass changes following a standardized exercise program.

Main Methods:

  • Cardiovascular magnetic resonance imaging (CMR) was used to measure LV mass in 301 army recruits before and after a 12-week training program.
  • Participants were genotyped for the CRP +1444C>T gene variant.
  • Changes in LV mass were analyzed in relation to CRP genotype.

Main Results:

  • LV mass increased with training in all subjects (+3.77 g).
  • The increase in LV mass was significantly greater in individuals homozygous for the T allele of the CRP +1444C>T variant (+8.17 g) compared to C-allele carriers (+3.37 g).
  • This difference was statistically significant (P = 0.033).

Conclusions:

  • The CRP genotype is associated with enhanced LV growth in response to exercise.
  • These findings support a potential causal link between CRP and LV growth.
  • Further research is needed to determine if the association is direct or mediated by other factors like arterial compliance.
Abstract

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