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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

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Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

From DNA to Protein

From DNA to Protein

The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...

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Related Experiment Video

Updated: Jun 19, 2026

High-throughput Yeast Plasmid Overexpression Screen

High-throughput Yeast Plasmid Overexpression Screen

Published on: July 27, 2011

Epigenetics to proteomics: from yeast to brain.

Purnima Bhargava¹

¹Centre for Cellular and Molecular Biology (Council of Scientific and Industrial Research), Tarnaka, Hyderabad, India. purnima@ccmb.res.in

|October 17, 2009

Summary

Epigenetics research in yeast provides insights into complex brain functions. Combining epigenetics and proteomics may unlock new brain disorder treatments and therapeutic targets.

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

The brain's complexity is poorly understood, with epigenetics emerging as a key factor.
Yeast, a simple eukaryote, has been crucial for understanding gene regulation in complex organisms.
Proteomics has significantly advanced brain biochemistry and physiology research.

Purpose of the Study:

To explore the role of epigenetics in normal brain function and disease.
To investigate the convergence of epigenetic and proteomic research.
To identify novel therapeutic targets for brain disorders.

Main Methods:

Leveraging knowledge from yeast epigenetics studies for gene regulation insights.
Utilizing proteomic approaches to study brain biochemistry and physiology.

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Integrating findings from independent epigenetic and proteomic research.

Main Results:

Epigenetic mechanisms are implicated in complex brain functions.
Advances in yeast epigenetics inform higher eukaryotic gene regulation.
Proteomic studies offer potential therapeutic targets for neurological conditions.

Conclusions:

The convergence of epigenetics and proteomics offers new avenues for understanding the brain.
Epigenetic insights can elucidate normal brain function and disease mechanisms.
Proteomic approaches are vital for discovering new therapeutic strategies for brain disorders.