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Updated: Jun 19, 2026
High-throughput Screening for Protein-based Inheritance in S. cerevisiae
Published on: August 8, 2017
[Screening and breeding of high lysine-producing strains by genome shuffling]
Kai Zhao1, Wei Duan, Lixin Sun
1Laboratory of Microbiology, College of Life Science, Heilongjiang University, Harbin 150080, China. zk395@yahoo.com.cn
Objective:
To screen and breed high lysine-producing strains by genome shuffling.
Methods:
Corynebacterium pekinense 1 was used as the starting strain in this study. High lysine-producing strains were screened by genome shuffling.
Results:
Five hereditarily stable strains with high lysine production were obtained by four cycles of genome shuffling. A high lysine producing strain, F4-36, was obtained, which produced 16.95 g/dL lysine, 37.1% higher than that of the starting strain.
Conclusion:
Genome shuffling can be an efficient tool to screen and breed high lysine production strains.
