Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Double-Blind Randomized Phase 2 Trial Testing Personal Cancer Vaccines in Patients with Advanced Ovarian Cancer.

Vaccines·2025

Same author

A review of vaccinology and <i>ex vivo</i> antigen-loaded dendritic cells: A different approach to infectious disease vaccines.

Human vaccines & immunotherapeutics·2025

Same author

Stem Cell Secretome Treatment Reduces Adiposity and Improves Glucose Handling During Obesity and Weight Loss in Mice.

Obesity (Silver Spring, Md.)·2025

Same author

Phase 2 trial of personal dendritic cell vaccines in newly diagnosed glioblastoma: 3-year follow-up and correlations with survival.

Human vaccines & immunotherapeutics·2025

Same author

Investment in Alzheimer's disease research for the next generation of adults with Down syndrome will yield health benefits for future generations.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Same author

Effect of immunosuppression on hESC-derived retina organoids in vitro and in vivo.

Stem cell research & therapy·2025

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Long-Term Mouse Spinal Cord Organotypic Slice Culture as a Platform for Validating Cell Transplantation in Spinal Cord Injury

Long-Term Mouse Spinal Cord Organotypic Slice Culture as a Platform for Validating Cell Transplantation in Spinal Cord Injury

Published on: April 12, 2024

Stem cells and spinal cord regeneration.

Sharyn L Rossi¹, Hans S Keirstead

¹Reeve-Irvine Research Center, Sue and Bill Gross Stem Cell Research Center, Department of Anatomy & Neurobiology, School of Medicine, 2111 Gillespie Neuroscience Research Facility, University of California at Irvine, Irvine, CA 92697-4292, USA.

Current Opinion in Biotechnology

|October 20, 2009

Summary

Cell transplantation aids spinal cord repair through combined trophic and phenotypic effects. Optimizing cell types and transplant sites enhances survival, differentiation, and regeneration for better outcomes.

More Related Videos

Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury

Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury

Published on: July 27, 2014

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

Related Experiment Videos

Last Updated: Jun 19, 2026

Long-Term Mouse Spinal Cord Organotypic Slice Culture as a Platform for Validating Cell Transplantation in Spinal Cord Injury

Long-Term Mouse Spinal Cord Organotypic Slice Culture as a Platform for Validating Cell Transplantation in Spinal Cord Injury

Published on: April 12, 2024

Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury

Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury

Published on: July 27, 2014

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

Area of Science:

Regenerative Medicine
Neuroscience
Cell Biology

Background:

Cell-based transplantation is a promising strategy for spinal cord repair.
Transplantation efficacy depends on cell properties and the transplant microenvironment.
Understanding repair mechanisms is crucial for optimizing cell therapies.

Purpose of the Study:

To investigate the mechanisms underlying cell transplantation for spinal cord repair.
To identify key pathways influencing transplant survival, differentiation, and tissue regeneration.
To explore how manipulating cells and their environment can improve therapeutic outcomes.

Main Methods:

Analyzing growth factor expression profiles of transplanted cells.
Evaluating the impact of transplant site on cell phenotype.
Investigating pathways for neuroprotection and endogenous tissue regeneration.
Utilizing high-purity stem cell populations to study lineage-specific repair.

Main Results:

Transplanted cell behavior (growth factor expression, phenotype) is influenced by cell type and transplant location.
Key pathways regulating transplant survival, differentiation, and neuroprotection were identified.
Stem cell-derived populations offer both neurotrophic and phenotypic benefits.

Conclusions:

Cell transplantation is a multifaceted approach to spinal cord injury (SCI) repair.
Optimizing cell populations and the microenvironment is essential for enhancing therapeutic efficacy.
Further research into lineage-specific mechanisms will advance stem cell-based SCI treatments.