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Updated: Jun 19, 2026
09:13
Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
Published on: November 1, 2011
Rift valley fever vaccines
Tetsuro Ikegami1, Shinji Makino
1Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555-0438, USA. teikegam@utmb.edu
Vaccine
|October 20, 2009
Summary
Rift Valley fever virus (RVFV) causes severe illness in humans and livestock. This review covers the development of inactivated, live attenuated, and novel RVFV vaccines for disease control.
Area of Science:
- Virology
- Epidemiology
- Vaccinology
Background:
- Rift Valley fever virus (RVFV) is a mosquito-borne Phlebovirus responsible for significant outbreaks in Africa and the Arabian Peninsula.
- RVFV infection leads to severe febrile illness, hemorrhagic fever, encephalitis, or ocular disease in humans, and abortions in ruminants.
Purpose of the Study:
- To summarize the development of various Rift Valley fever virus vaccines.
- To highlight effective vaccination strategies for controlling RVFV outbreaks in both human and animal populations.
Main Methods:
- Review of scientific literature on RVFV vaccine development.
- Analysis of different vaccine platforms including inactivated, live-attenuated, and next-generation approaches.
Main Results:
- Development of inactivated RVFV vaccines.
- Progress in creating live attenuated RVFV vaccines.
- Emergence of new generation RVFV vaccine candidates.
Conclusions:
- Vaccination is crucial for controlling Rift Valley fever.
- Diverse vaccine strategies are being pursued to combat RVFV.
- Ongoing vaccine development aims to provide effective protection against RVFV.
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