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Related Experiment Video

Updated: Jun 19, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

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Published on: May 31, 2016

Modafinil for multiple sclerosis fatigue: does it work?

Edward T Littleton1, Jeremy C Hobart, Jacqueline Palace

  • 1Department of Clinical Neurology, John Radcliffe Hospital, Headley Way, Oxford OX39DU, United Kingdom. LittletonEdward@aol.com

Clinical Neurology and Neurosurgery
|October 20, 2009
PubMed
Summary
This summary is machine-generated.

Modafinil may benefit multiple sclerosis (MS) patients with fatigue, especially when accompanied by sleepiness. This real-world audit found sustained benefits for fatigue and sleepiness in many MS patients.

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A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation (tDCS) in Multiple Sclerosis (MS)
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation (tDCS) in Multiple Sclerosis (MS)

Published on: December 26, 2015

Area of Science:

  • Neurology
  • Clinical Pharmacology

Background:

  • Multiple sclerosis (MS) fatigue is a common and disabling symptom.
  • Modafinil is prescribed for MS fatigue, but clinical trial results are inconsistent.

Purpose of the Study:

  • To audit the perceived effectiveness of modafinil for MS fatigue in a real-world clinical setting.
  • To evaluate long-term patient-reported outcomes and treatment continuation.

Main Methods:

  • Retrospective audit of MS patients initiated on modafinil for fatigue at the Oxford MS clinic.
  • Data collection included perceived benefit, side effects, and continuation decisions from medical notes.
  • Patients were interviewed up to 5 years post-treatment initiation.

Main Results:

  • 69% of patients with MS fatigue also experienced excessive daytime sleepiness.
  • Modafinil was perceived as more beneficial for sleepiness than fatigue.
  • Benefits for fatigue or sleepiness were generally sustained for a median of 1 year.

Conclusions:

  • Modafinil may be particularly useful for MS fatigue when associated with excessive daytime sleepiness.
  • The relationship between MS fatigue and sleepiness requires further investigation.
  • Existing clinical trial outcome measures may not adequately assess modafinil's effects in MS.