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Updated: Jun 19, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
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Published on: March 3, 2015

Protein-protein interaction networks: how can a hub protein bind so many different partners?

Chung-Jung Tsai1, Buyong Ma, Ruth Nussinov

  • 1Center for Cancer Research Nanobiology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA.

Trends in Biochemical Sciences
|October 20, 2009
PubMed

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Protein Networks02:26

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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Protein-Protein Interfaces02:04

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Protein Complexes with Interchangeable Parts01:57

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