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PI3K signaling in lymphocyte migration

Aurore Saudemont1, Francesco Colucci

  • 1Babraham Institute, Cambridge, UK. aurore.saudemont@anthonynolan.org.uk

Cell Cycle (Georgetown, Tex.)
|October 20, 2009
PubMed

Lymphocyte migration is crucial for immunological surveillance. A better understanding of the mechanisms that regulate lymphocyte migration will help appreciate how lymphocytes deliver specific functions to appropriate anatomical sites. Phosphoinositide-3 kinases (PI3Ks) are lipid kinases that regulate numerous cellular responses, including cell motility and chemotaxis. Here we discuss how PI3K isoforms differentially regulate lymphocyte migration and trafficking, with an emphasis on natural killer cells.

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