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Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

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Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
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Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

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The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
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Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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Related Experiment Video

Updated: Sep 15, 2025

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

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Innate Lymphoid Cells in Reproductive Health and Disease.

Francesco Colucci1, Marco Botta2

  • 1Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, UK.

European Journal of Immunology
|July 14, 2025
PubMed
Summary
This summary is machine-generated.

Innate lymphoid cells (ILC) in the uterus are crucial for endometrial repair and play vital roles during pregnancy, supporting placental formation and fetal growth. Understanding uterine ILC function is key to reproductive health.

Keywords:
NK cellsinnate immunityplacentareproductive immunologytrophoblast

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Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry
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Last Updated: Sep 15, 2025

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
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Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
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Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry
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Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry

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Area of Science:

  • Immunology
  • Reproductive Biology
  • Cell Biology

Background:

  • Innate lymphoid cells (ILC) are tissue-resident immune cells involved in tissue homeostasis and repair.
  • Uterine ILC are implicated in the cyclical changes of the endometrium and immune responses.
  • Their precise roles during pregnancy have been challenging to elucidate due to tissue accessibility and dynamic endometrial changes.

Purpose of the Study:

  • To review the existing literature on the function of uterine innate lymphoid cells (ILC).
  • To summarize the involvement of uterine ILC in both non-pregnant and pregnant states.
  • To highlight the contribution of uterine ILC to reproductive physiology and pathology.

Main Methods:

  • Literature review of existing studies on uterine ILC.
  • Synthesis of findings related to ILC function in the endometrium.
  • Analysis of ILC roles from implantation through parturition.

Main Results:

  • Uterine ILC contribute to endometrial cyclic destruction and repair.
  • These cells are essential for placental formation and fetal growth during pregnancy.
  • ILC orchestrate immune responses to maintain tissue health and respond to perturbations.

Conclusions:

  • Uterine ILC are critical immune regulators in the female reproductive tract.
  • Their functions extend from normal endometrial cycling to supporting a successful pregnancy.
  • Further research into uterine ILC is vital for understanding and potentially treating reproductive disorders.