Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...

Substance Use Disorders Affecting Sleep

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...

Drug Dependence

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...

Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.

CNS Depressants: Alcohol and Nicotine

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...

Longitudinal Research

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hypopituitarism following severe traumatic brain injury.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2006

Same author

The combination of increased ovarian volume and follicle number is associated with more severe hyperandrogenism in German women with polycystic ovary syndrome.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2006

Same author

[Subclinical hypothyroidism--what level of TSH is an indication for substitution?].

MMW Fortschritte der Medizin·2006

Same author

Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples.

Molecular psychiatry·2006

Same author

Repaglinide in the management of new-onset diabetes mellitus after renal transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2006

Same author

Elevated transaminases during medical treatment of acromegaly: a review of the German pegvisomant surveillance experience and a report of a patient with histologically proven chronic mild active hepatitis.

European journal of endocrinology·2006

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

[Addiction across the lifespan].

K Mann¹, M Laucht, S Weyerer

¹ZI - Zentralinstitut für Seelische Gesundheit, Universität Heidelberg, Mannheim. sucht@zi-mannheim.de

|October 20, 2009

Summary

This summary is machine-generated.

Alcohol and nicotine use pose significant public health risks, including fetal alcohol spectrum disorders and increased dementia cases in older adults. Early intervention and expanded specialist care are crucial for effective treatment of these substance-related disorders.

More Related Videos

A Conflict Model of Reward-seeking Behavior in Male Rats

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

Published on: March 15, 2024

Related Experiment Videos

Last Updated: Jun 19, 2026

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

A Conflict Model of Reward-seeking Behavior in Male Rats

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

Published on: March 15, 2024

Area of Science:

Public Health
Neuroscience
Addiction Medicine

Background:

Alcohol and nicotine are prevalent throughout the lifespan, posing significant health challenges.
Germany faces high rates of alcohol and nicotine consumption, leading to prevalent substance-related diseases.
Adolescent alcohol use contributes to accidents and suicides, with particular toxicity to the developing brain.

Purpose of the Study:

To highlight the prevalence and impact of alcohol and nicotine use in Germany.
To project the rise in alcohol-related problems and dementias in older adults.
To emphasize the need for expanded specialist care and effective prevention strategies.

Main Methods:

Analysis of current public health data on alcohol and nicotine consumption.
Projection of future trends in substance-related disorders, particularly in aging populations.
Review of existing treatment effectiveness and prevention strategies.

Main Results:

Approximately 4,000 children annually are born with Fetal Alcohol Syndrome (FAS) and 20,000 with Fetal Alcohol Effects (FAE) in Germany.
Alcohol problems in individuals aged 65 and older are projected to double in the next decade, increasing alcohol-related dementias.
Less than 10% of patients receive specialist care, despite treatment effectiveness for chronic relapsing disorders.

Conclusions:

Substance-related disorders, particularly alcohol use, represent a growing public health concern requiring urgent attention.
There is a critical need to expand access to specialist care, involving psychiatrists and psychotherapists.
Prevention strategies must be enhanced, potentially through revised policies on advertising and taxation, to curb overall consumption.