Is Hsp27 a marker of myocardial ischaemia?
Grazyna Józefowicz-Okonkwo1, Karina Wierzbowska-Drabik, Marek Kasielski
1Medical University, Lodz, Poland. gokonkwo@zdn.umed.lodz.pl
Insights
Serum heat shock protein 27 (Hsp27) levels may indicate myocardial ischemia in patients with advanced coronary artery disease (CAD). Higher Hsp27 levels were observed in individuals with multi-vessel CAD compared to controls.
Area of Science:
- Cardiology
- Biochemistry
- Molecular Biology
Background:
- Heat shock protein (Hsp27) expression elevates in cardiomyocytes during ischemia.
- Extracellular Hsp27 release from cardiomyocytes correlates with intracellular levels.
Purpose of the Study:
- To investigate the association between significant coronary artery disease (CAD) and serum Hsp27 levels.
- To determine if chronic myocardial ischemia, a hallmark of CAD, influences circulating Hsp27.
Main Methods:
- Serum Hsp27 levels were measured in 62 patients with significant CAD (≥50% coronary artery narrowing) and 21 healthy controls.
- Coronary angiography was used to assess CAD severity and number of affected vessels.
Main Results:
- Patients with CAD showed a trend towards higher serum Hsp27 than controls (p=0.084).
- Significantly elevated serum Hsp27 was found in patients with multi-vessel CAD compared to controls (p=0.035) and single-vessel CAD (p=0.041).
- No correlation was observed between serum Hsp27 levels and the Gensini score (r=0.21, p=0.11).
Conclusions:
- Serum Hsp27 may serve as a potential biomarker for myocardial ischemia.
- Elevated serum Hsp27 is associated with advanced (2- or 3-vessel) coronary artery disease.
Background:
Heat shock protein (Hsp) 27 expression in cardiomyocytes increases in response to ischaemia. The extracellular release of Hsp27 from cardiomyocytes is proportional to its intracellular levels.
Aim:
To assess the influence of significant coronary artery disease (CAD), which by definition results in chronic myocardial ischaemia, on blood serum levels of Hsp27.
Methods:
Blood serum levels of Hsp27 in 62 patients with at least 50% lumen diameter narrowing in at least one main epicardial coronary artery on angiography and in 21 controls with normal coronaries were measured.
Results:
Patients with CAD tended to have higher serum level of Hsp27 than controls [0.463 (0.158-0.809) vs. 0.184 (0.099-0.337) ng/ml, p = 0.084]. Serum Hsp27 level in patients with CAD affecting more than a single vessel was significantly increased [0.529 (0.192-1.004) ng/ml] compared with controls (p = 0.035) and with one artery narrowed [0.276 (0.087-0.549) ng/ml, p = 0.041]. No correlation between Hsp27 serum levels and severity of coronary narrowings assessed by Gensini score was found (r = 0.21, p = 0.11).
Conclusions:
Serum level of Hsp27 seems to be a potential marker of myocardial ischaemia caused by advanced 2- or 3-vessel CAD.
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