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The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
[When an antidepressant helps too much]
1Turun yliopisto ja Satakunnan Psykiatripalvelu Oy, Rauman Erikoislääkärikeskus Valtakatu 9-11, Rauma.
Abstract:
Initiation of an antidepressant may result in hypomania or mania. The risk is lower with selective serotonin reuptake inhibitors and bupropione than with venlafaxine and tricyclic antidepressants. With a mood-stabilizing medication, the risk of hypomania or mania will remain very low, along with its correspondingly lower efficacy. The therapy involves discontinuation of the antidepressant, initiation or dose elevation of a maintenance drug preventing hypomania and mania, and when needed, short-course use of a second generation antipsychotic.
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