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Published on: August 15, 2016
Physicochemical characterization and in vitro dissolution behaviour of celecoxib-beta-cyclodextrin inclusion
Vivek Ranjan Sinha1, R Anitha, Soma Ghosh
1University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. vr_sinha@yahoo.com
Acta Pharmaceutica (Zagreb, Croatia)
|October 21, 2009
Summary
Beta-cyclodextrin (beta-CD) inclusion complexes significantly enhanced the aqueous solubility and dissolution rate of celecoxib. This indicates beta-CD is effective for improving the bioavailability of poorly soluble drugs like celecoxib.
Area of Science:
- Pharmaceutical Sciences
- Physical Chemistry
Background:
- Celecoxib is a poorly soluble nonsteroidal anti-inflammatory drug.
- Improving the solubility and dissolution rate of celecoxib is crucial for enhancing its therapeutic efficacy.
Purpose of the Study:
- To investigate the impact of beta-cyclodextrin (beta-CD) on the aqueous solubility and dissolution rate of celecoxib.
- To prepare and characterize beta-CD-celecoxib inclusion complexes.
Main Methods:
- Inclusion complexes were prepared using the kneading method.
- Characterization involved Scanning Electron Microscopy (SEM), Nuclear Magnetic Resonance (NMR), Infrared Spectroscopy (IR), Differential Scanning Calorimetry (DSC), and X-ray Powder Diffraction (XRPD).
- Dissolution rates were compared between inclusion complexes, physical mixtures, and the pure drug.
Main Results:
- The formation of beta-CD-celecoxib inclusion complexes was confirmed through various characterization techniques.
- Dissolution rate of the inclusion complexes was markedly higher compared to physical mixtures and pure celecoxib.
- The study demonstrated a significant increase in the solubility of celecoxib upon complexation with beta-CD.
Conclusions:
- Beta-cyclodextrin effectively forms inclusion complexes with celecoxib.
- Complexation with beta-CD significantly enhances the aqueous solubility and dissolution rate of celecoxib.
- Beta-cyclodextrin holds potential for improving the formulation and bioavailability of celecoxib.
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