Related Experiment Video
Updated: Jun 19, 2026

Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in pulmonary squamous cell
1Department of Thoracic Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China. changdongj@yahoo.com.cn
Objective:
To investigate the role of stomatin-like protein 2 (SLP-2), a novel cancer-related gene, in pulmonary squamous cell carcinoma (PSCC) and its implications.
Methods:
Immunohistochemical detection of SLP-2 was performed on 96 cases of PSCC with a tissue microarray.
Results:
SLP-2 was overexpressed in lung cancer compared with normal lung tissue (p <0.001). High-level SLP-2 expression was significantly correlated with distant metastasis (p = 0.025), decreased overall survival (p = 0.018) and disease-free survival (p = 0.017). SLP-2 overexpression was an independent prognostic factor in multivariate analysis using the Cox regression model (p <0.05).
Conclusion:
SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in PSCC. SLP-2 could be regarded as a new significant prognostic biomarker for patients with PSCC.
Related Concept Videos
Abnormal Proliferation
lncRNA - Long Non-coding RNAs