Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kidney Stone Research in the Rochester Epidemiology Project.

Mayo Clinic proceedings·2026
Same author

Accuracy and precision of automated kidney stone detection on CT.

Abdominal radiology (New York)·2026
Same author

Database of <i>CLCN5</i> Pathogenic Variants Causing Dent Disease.

Kidney international reports·2026
Same author

Differences between cystatin C- and creatinine-based estimated glomerular filtration rate and the risks of postoperative complications and mortality.

Journal of clinical anesthesia·2026
Same author

Prevention of urinary stones with hydration: a randomised clinical trial of an adherence intervention.

Lancet (London, England)·2026
Same author

The Significance of Fibroblast Growth Factor 23 and 24,25-Dihydroxyvitamin D in Dent Disease Type 1.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same journal

Lipid-based nanocarriers as transformative treatment in tuberculosis: a systematic review of therapeutic efficacy.

Nanomedicine (London, England)·2026
Same journal

UCMSC-Exo for chemotherapy-induced myelosuppression in acute myeloid leukemia: a phase I clinical trial protocol.

Nanomedicine (London, England)·2026
Same journal

Aptamer-functionalized nanoparticles for cancer targeting: conjugation strategies, current applications and future perspectives.

Nanomedicine (London, England)·2026
Same journal

Targeted therapy of highly aggressive thyroid papillary carcinoma by AS1411-guided nanomaterials.

Nanomedicine (London, England)·2026
Same journal

Impacts of curcumin nanoemulgel on cell viability and apoptotic pathways: a comprehensive study of ROS generation across different skin cancer cell lines.

Nanomedicine (London, England)·2026
Same journal

Advancements in single-chain antibody functionalized nanoparticles for the treatment of advanced solid tumors.

Nanomedicine (London, England)·2026
See all related articles

Related Experiment Video

Updated: Jun 19, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Biologic nanoparticles and platelet reactivity.

Virginia M Miller1, Larry W Hunter, Kevin Chu

  • 1Department of Surgery, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. miller.virginia@mayo.edu

Nanomedicine (London, England)
|October 21, 2009
PubMed
Summary
This summary is machine-generated.

Biologic nanoparticles (NPs) derived from human or bovine tissue, and hydroxyapatite crystals, were found to inhibit platelet aggregation. These NPs may reduce blood coagulability and vascular response to injury.

More Related Videos

Ferric Chloride-induced Murine Thrombosis Models
10:37

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

Related Experiment Videos

Last Updated: Jun 19, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Ferric Chloride-induced Murine Thrombosis Models
10:37

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

Area of Science:

  • Biomaterials Science
  • Hematology
  • Nanotechnology

Background:

  • Nanosized particles (NPs) from calcified tissue accelerate arterial occlusion.
  • Platelet aggregation and secretion are key in hemostasis, thrombosis, and vascular remodeling.

Purpose of the Study:

  • To investigate the in vitro effects of biologic NPs on human platelet function.
  • To determine if NPs alter platelet aggregation and adenosine triphosphate (ATP) secretion.

Main Methods:

  • Human platelet-rich plasma was incubated with human-derived NPs, bovine-derived NPs, or hydroxyapatite crystals.
  • Platelet aggregation and ATP secretion were measured in response to specific agonists.

Main Results:

  • Both human and bovine NPs reduced platelet aggregation concentration-dependently.
  • Hydroxyapatite crystals showed greater inhibition of aggregation than biologic NPs.
  • Human-derived NPs increased ATP secretion in unstimulated platelets.

Conclusions:

  • Biologic NPs and hydroxyapatite modulate platelet aggregation and secretion.
  • These NPs may reduce blood coagulability and the vascular response to injury.