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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

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Related Experiment Video

Updated: Jun 19, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Allergic asthma in patients with common variable immunodeficiency.

R C Agondi¹, M T Barros, L V Rizzo

¹Department of Clinical Immunology and Allergy, University of São Paulo, Brazil.

|October 21, 2009

Summary

This summary is machine-generated.

Common variable immunodeficiency (CVID) patients often show asthma symptoms. This study found obstructive lung disease in nearly half of CVID patients and identified allergic asthma in some, even with negative allergy tests.

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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

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Published on: June 4, 2017

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Last Updated: Jun 19, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Area of Science:

Immunology
Pulmonology
Allergy

Background:

Many patients with common variable immunodeficiency (CVID) present with symptoms suggestive of allergic respiratory disease.
The prevalence of asthma and the role of atopy in CVID patients remain unclear.
Investigating pulmonary function and asthma in CVID is crucial for patient management.

Purpose of the Study:

To evaluate pulmonary function in CVID patients.
To identify asthma prevalence and characteristics in CVID.
To determine the role of immunoglobulin E (IgE) in triggering asthma in CVID.

Main Methods:

Sixty-two CVID patients underwent spirometry.
Skin prick testing and serum-specific IgE levels for aeroallergens were performed.
Bronchial provocation tests with histamine and allergens were conducted.

Main Results:

Obstructive lung disease was the most common spirometry finding (47.5%).
Asthma was diagnosed in 14.5% of patients; atopy in 9.7%.
Allergic asthma was diagnosed in 6.5% of patients, including some with negative IgE tests.

Conclusions:

CVID patients with suspected allergic asthma and negative IgE tests can show positive responses to allergen bronchial provocation.
This suggests traditional allergy tests may underestimate allergic asthma in CVID.
Further diagnostic approaches are recommended for CVID patients with suspected allergic asthma who test negative on standard tests.