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Related Experiment Video

Updated: Jun 19, 2026

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Published on: November 10, 2023

[Interaction between mixed-lineage leukemia and Menin proteins].

Lin Liu¹, Ben-Shang Li, Qi-Dong Ye

¹Department of Hematology and Oncology, Shanghai Children Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi

|October 21, 2009

Summary

Mixed-lineage leukemia (MLL) and Menin proteins interact and are found together in cell nuclei. This study confirms their co-localization and binding within the nucleus.

Related Experiment Videos

Last Updated: Jun 19, 2026

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Published on: November 10, 2023

Area of Science:

Molecular Biology
Cell Biology
Protein Interactions

Context:

The study investigates the subcellular localization and interaction of mixed-lineage leukemia (MLL) and Menin proteins.
Understanding protein localization and interaction is crucial for elucidating cellular functions and disease mechanisms.

Purpose:

To determine the subcellular localization of MLL and Menin proteins.
To investigate the interaction between MLL and Menin proteins in vivo.

Summary:

Recombinant eukaryotic expression vectors for MLL and Menin were constructed and transfected into HEK293T cells.
Immunofluorescence, co-immunoprecipitation, and Western blot techniques were employed to analyze protein localization and interaction.
Results demonstrated that MLL and Menin proteins co-localize in the cell nucleus and physically interact.

Impact:

Provides evidence for the nuclear co-localization and interaction of MLL and Menin proteins.
Contributes to the understanding of the molecular mechanisms involving MLL and Menin in cellular processes.
Establishes a foundation for further research into the functional significance of the MLL-Menin complex.