Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

Interactions Between Signaling Pathways

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Involvement of mitochondrial permeability transition in hepatitis B virus replication.

Virus research·2009

Same author

Synthesis of 3-sulfenyl- and 3-selenylindoles by the Pd/Cu-catalyzed coupling of N,N-dialkyl-2-iodoanilines and terminal alkynes, followed by n-Bu(4)NI-induced electrophilic cyclization.

The Journal of organic chemistry·2009

Same author

The prognostic value of immunohistochemical subtyping in Chinese patients with de novo diffuse large B-cell lymphoma undergoing CHOP or R-CHOP treatment.

Annals of hematology·2009

Same author

Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting Rho kinase-mediated Ezrin phosphorylation at threonine 567.

The Journal of biological chemistry·2009

Same author

Removal of posterior longitudinal ligament in anterior decompression for cervical spondylotic myelopathy.

Journal of spinal disorders & techniques·2009

Same author

Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator.

Journal of hypertension·2009

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

[Notch signaling pathway and multiple myeloma].

Zhi-Hua Gan¹, Yu Chen

¹Department of Hematology, Ruijing Hospital, Shanghai Jiaotong University Medical College, Shanghai 200025, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi

|October 21, 2009

Summary

Inhibiting the Notch signaling pathway, crucial for cell interactions, shows promise in treating multiple myeloma. Targeting Jagged2 overexpression can induce cancer cell death and enhance chemotherapy effectiveness.

Area of Science:

Cellular Biology
Molecular Biology
Cancer Biology

Context:

The Notch signaling pathway regulates cell-cell interactions, influencing proliferation, differentiation, and apoptosis across various cell types.
In the hematopoietic system, Notch signaling is vital for maintaining the balance between cell proliferation and differentiation, and its dysregulation is linked to hematologic malignancies.
Multiple myeloma (MM) is a B-cell malignancy characterized by drug-resistant plasma cells, posing significant treatment challenges.

Purpose:

To review the composition and mechanism of the Notch signaling pathway.
To elucidate the relationship between Notch signaling and the pathogenesis of multiple myeloma.
To explore the therapeutic potential of inhibiting Notch signaling in MM.

Summary:

More Related Videos

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

Related Experiment Videos

Last Updated: Jun 19, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

Jagged2, a Notch ligand, is overexpressed in malignant plasma cells of MM patients, unlike in normal cells or other cancers.
Jagged2 overexpression promotes MM cell proliferation and drug resistance by inducing stromal cells to secrete growth factors and interacting with key cellular pathways (NF-kappaB, C-myc).
Specific inhibition of Notch signaling using gamma-secretase inhibitors (GSIs) induces apoptosis in MM cells and sensitizes them to chemotherapy.

Impact:

Targeting the Notch pathway, particularly Jagged2, offers a novel therapeutic strategy for multiple myeloma.
Inhibition of Notch signaling can overcome drug resistance in MM, potentially improving patient outcomes.
Combining gamma-secretase inhibitors with chemotherapy may enhance treatment efficacy for multiple myeloma patients.