Related Experiment Video
Updated: Jun 19, 2026

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
Published on: December 8, 2017
The stressed CNS: when glucocorticoids aggravate inflammation
Shawn F Sorrells1, Javier R Caso, Carolina D Munhoz
1Department of Biological Sciences, Stanford University, Gilbert Lab MC 5020, Stanford, CA 94305-5020, USA. sfs11@stanford.edu
Abstract:
Glucocorticoids (GCs) are hormones released during the stress response that are well known for their immunosuppressive and anti-inflammatory properties; however, recent advances have uncovered situations wherein they have effects in the opposite direction. The CNS is a particularly interesting example, both because of its unique immune environment, and because GCs affect immune responses differently in different brain regions. In this minireview we discuss the contexts wherein GCs increase CNS inflammation and point out directions for future investigation.
Related Concept Videos
Hypothalamic-Pituitary Axis
Cushing Syndrome II: Pathophysiology
Chronic Inflammation: Introduction
Physiological Foundation of Stress
Role of the Sympathetic Nervous System
Adrenaline triggers the...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
