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Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
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Dynamic contrast-enhanced diffuse optical tomography (DCE-DOT): experimental validation with a dynamic phantom.

Mehmet Burcin Unlu1, Yuting Lin, Gultekin Gulsen

  • 1Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92617, USA.

Physics in Medicine and Biology
|October 21, 2009
PubMed
Summary
This summary is machine-generated.

Dynamic contrast-enhanced diffuse optical tomography (DCE-DOT) accurately recovers indocyanine green (ICG) kinetics. Phantom studies show DCE-DOT is robust to inclusion size, depth, and background optical properties, even with structural prior errors.

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Pharmacokinetics

Background:

  • Dynamic contrast-enhanced diffuse optical tomography (DCE-DOT) offers spatially resolved enhancement kinetics of optical contrast agents.
  • Indocyanine green (ICG) is a widely used optical contrast agent in DCE-DOT.

Purpose of the Study:

  • To systematically evaluate the impact of geometrical and optical parameters on DCE-DOT recovered enhancement kinetics.
  • To assess the robustness of DCE-DOT in recovering ICG kinetics under varying phantom conditions and structural prior uncertainties.

Main Methods:

  • A computer-controlled dynamic phantom was utilized to simulate tissue environments.
  • DCE-DOT measurements were acquired with a temporal resolution of 16 seconds using ICG-intralipid-water mixtures.
  • Phantom studies systematically varied inclusion size, depth, background optical properties, and structural prior information.

Main Results:

  • Recovered injection and dilution rates from percentage enhancement maps agreed within 15% across different inclusion sizes and depths.
  • Results were independent of non-scattering regions in the background.
  • Injection and dilution rates showed resilience to systematic errors in structural prior selection, with minor changes (<10%) even with a 20% smaller inclusion diameter.

Conclusions:

  • DCE-DOT reliably quantifies ICG kinetics, demonstrating robustness against variations in inclusion geometry and background optical properties.
  • The method is resilient to inaccuracies in structural prior information, crucial for clinical applications.
  • Further investigation may be needed for very small or deeply embedded objects where structural priors are critical.