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Reirradiation for progressive brain metastases.
Amit Bahl1, Milind Kumar, D N Sharma
1Department of Radiation Oncology, Delhi State Cancer Institute, New Delhi, India. dramitbahl@yahoo.com
Journal of Cancer Research and Therapeutics
|October 21, 2009
Summary
Reirradiation offers a viable, underutilized option for patients with progressing brain metastases after initial radiotherapy. This approach can alleviate symptoms and improve survival with minimal side effects.
Area of Science:
- Neuro-oncology
- Radiation Oncology
Background:
- Brain metastases are common and often require radiotherapy.
- Over half of patients experience disease progression after initial treatment, creating a therapeutic challenge.
Purpose of the Study:
- To review reirradiation as a treatment modality for brain metastases.
- To evaluate the efficacy and safety of reirradiation techniques.
Main Methods:
- Literature search of MEDLINE (PubMed) using keywords: brain metastases, reirradiation, whole brain radiotherapy, stereotactic radiosurgery, interstitial brachytherapy.
- Limited to English literature and human subjects.
Main Results:
- Reirradiation is an underutilized option for progressing brain metastases.
- Reirradiation can resolve symptoms and improve survival with minimal late neurotoxicity.
- Both whole brain radiotherapy and stereotactic radiosurgery show promising results for reirradiation.
Conclusions:
- Reirradiation is a valuable treatment option for patients with recurrent or progressive brain metastases.
- Further investigation into optimal reirradiation strategies is warranted.
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