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Published on: February 7, 2019
Mechanistic studies on a dipeptide-promoted asymmetric cyclopropanation of unfunctionalized olefins
Jiang Long1, Liang Xu, Haifeng Du
1Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
Abstract:
This paper describes mechanistic studies on a dipeptide-promoted asymmetric cyclopropanation system for unfunctionalized olefins. Zinc species generated from the deprotonation of the N-H of the dipeptide ligand have been investigated by NMR and X-ray structure studies and are likely to be responsible for asymmetric cyclopropanation. ZnI(2) plays an important role in promoting the reaction.
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