Related Experiment Video
Updated: Jun 19, 2026

Detection of Homologous Recombination Intermediates via Proximity Ligation and Quantitative PCR in Saccharomyces cerevisiae
Published on: September 11, 2022
Time to fixation in the presence of recombination
1Theoretical Sciences Unit and Evolutionary and Organismal Biology Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bangalore 560064, India. jain@jncasr.ac.in
Abstract:
We study the evolutionary dynamics of a haploid population of infinite size recombining with a probability r in a two locus model. Starting from a low fitness locus, the population is evolved under mutation, selection and recombination until a finite fraction of the population reaches the fittest locus. An analytical method is developed to calculate the fixation time T to the fittest locus for various choices of epistasis. We find that: (1) for negative epistasis, T decreases slowly for small r but decays fast at larger r; (2) for positive epistasis, T increases linearly for small r and mildly for large r; (3) for compensatory mutation, T diverges as a power law with logarithmic corrections as the recombination fraction approaches a critical value. Our calculations are seen to be in good agreement with the exact numerical results.
Related Concept Videos
Crossing Over
Crossing Over
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
Conservative Site-specific Recombination and Phase Variation
The recognition sites for Cre recombinase called LoxP...
Homologous Recombination
Homologous Recombination
Fixing Double-strand Breaks

