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Updated: Jun 19, 2026

Synthesis and Assay of Vibrio Quorum Sensing Inhibitors
Published on: May 31, 2024
A model for signal transduction during quorum sensing in Vibrio harveyi
Suman K Banik1, Andrew T Fenley, Rahul V Kulkarni
1Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0435, USA. skbanik@vt.edu
Abstract:
We present a framework for analyzing luminescence regulation during quorum sensing in the bioluminescent bacterium Vibrio harveyi. Using a simplified model for signal transduction in the quorum sensing pathway, we identify key dimensionless parameters that control the system's response. These parameters are estimated using experimental data on luminescence phenotypes for different mutant strains. The corresponding model predictions are consistent with results from other experiments which did not serve as input for determining model parameters. Furthermore, the proposed framework leads to novel testable predictions for luminescence phenotypes and for responses of the network to different perturbations.
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