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Published on: August 15, 2016
Taste masking of Etoricoxib by using ion-exchange resin
Sradhanjali Patra1, Rakesh Samantaray, Saswat Pattnaik
1University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar, Orissa, India. sradhanjali2002@yahoo.co.in
Abstract:
The present study was carried out in order to mask the bitter taste of the Etoricoxib by complexation with cation-exchange resin, Indion 204. The drug resin complexes (DRC) were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drug-resin ratio 1:3.3 with 30 min swelling time of resin in 25 mL of water with 5 min stirring time. Drug-resin complexes were characterized for dissolution studies and spectral studies. Drug release from drug-resin complex in salivary pH was insufficient to impart bitter taste. Volunteers rated the drug resin complex as tasteless and agreeable.
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