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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
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Diabetes and benign prostatic hyperplasia/lower urinary tract symptoms--what do we know?
Aruna V Sarma1, J Kellogg Parsons, Kevin McVary
1Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA. asarma@umich.edu
The Journal of Urology
|October 23, 2009
Summary
Diabetes may increase the risk of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) in older men. Further research is needed to understand the mechanisms and develop interventions.
Area of Science:
- Urology
- Endocrinology
- Public Health
Background:
- Benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) are common in aging men.
- The etiology and natural history of BPH/LUTS are not well understood.
- Emerging evidence suggests a link between diabetes and BPH/LUTS.
Purpose of the Study:
- To review current clinical and epidemiological research on diabetes and BPH/LUTS.
- To explore hypothesized pathophysiological mechanisms linking diabetes and BPH/LUTS.
- To recommend future research directions.
Main Methods:
- A structured, comprehensive literature review was conducted.
- Studies investigating the relationship between BPH/LUTS and diabetes in older men were identified.
Main Results:
- A significant body of literature supports an association between diabetes and BPH/LUTS.
- Confusing evidence may stem from undifferentiated LUTS and BPH, cross-sectional analyses, small sample sizes, and inadequate confounder control.
Conclusions:
- Diabetes may significantly impact the risk of BPH and LUTS in older men.
- Prospective, longitudinal studies are needed to elucidate etiological mechanisms.
- Further research could lead to novel interventions for BPH/LUTS.
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