Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
Ovaries01:26

Ovaries

The ovaries are roughly the size of almonds and measure approximately 2 to 3 centimeters in length. These paired structures are situated within the pelvic region and are anchored by the mesovarium—a peritoneal extension that also connects them to the wider structure of the broad ligament. The support system extends to the suspensory ligament, housing blood and lymphatic vessels. In addition, the ovarian ligament tethers the ovaries to the uterus.
On the ovarian surface, a layer of cuboidal...
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
The Nucleolus02:55

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development, internal and external evaluation of an artificial intelligence algorithm for child growth monitoring in primary care.

PLOS digital health·2026
Same author

Astrocytes exploit a neutrophil extracellular trap - like mechanism for myelin management: A new perspective on myelin-related disorders.

Brain, behavior, and immunity·2026
Same author

Assessment and supplementation of antioxidant amines in male infertility-are we approaching clinical implementation?

Molecular human reproduction·2026
Same author

[Testicular telocyte: a player in the regulation of spermatogenesis?]

Medecine sciences : M/S·2026
Same author

A novel candidate missense variant in the catalytic domain of USP26 associated with asthenoteratozoospermia.

Gene·2025
Same author

Primary ovarian insufficiency due to homozygous variants in the homeobox transcription factor NOBOX.

Molecular biology reports·2025

Related Experiment Video

Updated: Jun 19, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

[NR5A1 and ovarian failure].

Anu Bashamboo1, Celia Ravel, Raja Brauner

  • 1Human Developmental Genetics, Institut Pasteur, 25-28, rue du Docteur Roux, 75724 Paris Cedex 15, France. bashamboo@hotmail.co.uk

Medecine Sciences : M/S
|October 24, 2009
PubMed
Summary

Mutations in the NR5A1 gene are linked to primary ovarian insufficiency (POI), a condition affecting women under 40. This discovery highlights NR5A1's crucial role in ovarian development and function.

Area of Science:

  • Genetics
  • Reproductive Endocrinology
  • Developmental Biology

Context:

  • Primary ovarian insufficiency (POI) affects 1% of women under 40, often with a familial inheritance pattern.
  • NR5A1, a nuclear receptor, is vital for sexual development and reproduction, with known mutations linked to adrenal and testis anomalies.
  • Previous research identified 18 NR5A1 mutations, but their role in ovarian function was unclear.

Purpose:

  • To investigate the role of NR5A1 mutations in primary ovarian insufficiency.
  • To determine the incidence and genotype/phenotype relationship of NR5A1 mutations in POI patients.
  • To explore if NR5A1 mutations are associated with a progressive decline in reproductive function.

Summary:

  • This study identified NR5A1 mutations in patients with primary ovarian insufficiency, including familial cases and individuals with 46,XY karyotype.

More Related Videos

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation
05:42

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation

Published on: October 25, 2024

Related Experiment Videos

Last Updated: Jun 19, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation
05:42

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation

Published on: October 25, 2024

  • The findings confirm NR5A1's significant role in ovarian development and function.
  • Open questions include the mutation incidence in POI, genotype-phenotype correlations, and the association with progressive reproductive dysfunction.

    • Impact:

    • Advances understanding of the genetic basis of ovarian development and dysfunction.
    • Provides a foundation for further research into NR5A1's precise mechanisms in the ovary.
    • May pave the way for novel therapeutic strategies for primary ovarian insufficiency.